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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Burazin, T C | en |
dc.contributor.author | Gundlach, Andrew L | en |
dc.date.accessioned | 2015-05-16T03:14:59Z | |
dc.date.available | 2015-05-16T03:14:59Z | |
dc.date.issued | 1995-10-02 | en |
dc.identifier.citation | Neuroreport; 6(14): 1842-4 | en |
dc.identifier.govdoc | 8547580 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13405 | en |
dc.description.abstract | Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confirms the heterogeneous distribution of the NOS enzyme. [3H]L-NOARG binding was enriched in discrete neuronal populations and the distribution observed was identical to that previously described for NOS using immunohistochemistry, in situ hybridization and NADPH-diaphorase staining. [3H]L-NOARG autoradiography should be a useful method for the further characterization and quantification of NOS in brain and other tissues. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Arginine.analogs & derivatives.metabolism | en |
dc.subject.other | Autoradiography | en |
dc.subject.other | Enzyme Inhibitors.metabolism | en |
dc.subject.other | Male | en |
dc.subject.other | Nitric Oxide Synthase.analysis.antagonists & inhibitors | en |
dc.subject.other | Nitroarginine | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Sprague-Dawley | en |
dc.subject.other | Rats, Wistar | en |
dc.subject.other | Tritium.diagnostic use | en |
dc.title | Localization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Neuroreport | en |
dc.identifier.affiliation | University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia | en |
dc.description.pages | 1842-4 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/8547580 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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