Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13405
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dc.contributor.authorBurazin, T Cen
dc.contributor.authorGundlach, Andrew Len
dc.date.accessioned2015-05-16T03:14:59Z
dc.date.available2015-05-16T03:14:59Z
dc.date.issued1995-10-02en
dc.identifier.citationNeuroreport; 6(14): 1842-4en
dc.identifier.govdoc8547580en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13405en
dc.description.abstractNitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confirms the heterogeneous distribution of the NOS enzyme. [3H]L-NOARG binding was enriched in discrete neuronal populations and the distribution observed was identical to that previously described for NOS using immunohistochemistry, in situ hybridization and NADPH-diaphorase staining. [3H]L-NOARG autoradiography should be a useful method for the further characterization and quantification of NOS in brain and other tissues.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherArginine.analogs & derivatives.metabolismen
dc.subject.otherAutoradiographyen
dc.subject.otherEnzyme Inhibitors.metabolismen
dc.subject.otherMaleen
dc.subject.otherNitric Oxide Synthase.analysis.antagonists & inhibitorsen
dc.subject.otherNitroarginineen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherRats, Wistaren
dc.subject.otherTritium.diagnostic useen
dc.titleLocalization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroreporten
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australiaen
dc.description.pages1842-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8547580en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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