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|Title:||Localization of NO synthase in rat brain by [3H]L-NG-nitro-arginine autoradiography.||Austin Authors:||Burazin, T C;Gundlach, Andrew L||Affiliation:||University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia||Issue Date:||2-Oct-1995||Publication information:||Neuroreport; 6(14): 1842-4||Abstract:||Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confirms the heterogeneous distribution of the NOS enzyme. [3H]L-NOARG binding was enriched in discrete neuronal populations and the distribution observed was identical to that previously described for NOS using immunohistochemistry, in situ hybridization and NADPH-diaphorase staining. [3H]L-NOARG autoradiography should be a useful method for the further characterization and quantification of NOS in brain and other tissues.||Gov't Doc #:||8547580||URI:||http://ahro.austin.org.au/austinjspui/handle/1/13405||URL:||https://pubmed.ncbi.nlm.nih.gov/8547580||Type:||Journal Article||Subjects:||Animals
Arginine.analogs & derivatives.metabolism
Nitric Oxide Synthase.analysis.antagonists & inhibitors
|Appears in Collections:||Journal articles|
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