Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13350
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dc.contributor.authorRubinstein, Gen
dc.date.accessioned2015-05-16T03:11:07Z
dc.date.available2015-05-16T03:11:07Z
dc.date.issued1993-08-01en
dc.identifier.citationSchizophrenia Research; 10(2): 95-102en
dc.identifier.govdoc8398951en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13350en
dc.description.abstractTwo factors which seem to have a significant role in schizophrenia are infection and temperature. Evidence is presented that the schizophrenic population may be part of a sub-population which has preferential resistance to epidemic infection. This characteristic alone may not be responsible for vulnerability to schizophrenia. Part at least of the genetic predisposition to schizophrenia may lie in an abnormal response to hormonal disturbances in the intrauterine environment which may result from prenatal viral infection; this abnormal response may cause neurodevelopmental damage. Then in effect the vulnerability of some to schizophrenia will be the cost of population survival in epidemics. Dopamine is involved in central thermoregulation, and may be involved in response to infection. In two inbred mouse strains, one virus-resistant and the other virus-susceptible, there is also a difference in core body temperature response to dopamine. Because of the connection of dopamine sensitivity, temperature and resistance to infection the paired mouse strains are suggested as an animal model for studies relevant to schizophrenia.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBody Temperature Regulation.physiologyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherDiseases in Twinsen
dc.subject.otherDopamine.physiologyen
dc.subject.otherFemaleen
dc.subject.otherGene Poolen
dc.subject.otherHumansen
dc.subject.otherInfection.complications.physiopathologyen
dc.subject.otherLimbic System.physiopathologyen
dc.subject.otherMiceen
dc.subject.otherMice, Inbred Strainsen
dc.subject.otherPregnancyen
dc.subject.otherPrenatal Exposure Delayed Effectsen
dc.subject.otherRisk Factorsen
dc.subject.otherSchizophrenia.etiology.genetics.physiopathologyen
dc.subject.otherSchizophrenic Psychologyen
dc.titleSchizophrenia, infection and temperature. An animal model for investigating their interrelationships.en
dc.typeJournal Articleen
dc.identifier.journaltitleSchizophrenia researchen
dc.identifier.affiliationUniversity of Melbourne Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages95-102en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8398951en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
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