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Title: Schizophrenia, infection and temperature. An animal model for investigating their interrelationships.
Austin Authors: Rubinstein, G
Affiliation: University of Melbourne Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1993
Publication information: Schizophrenia Research; 10(2): 95-102
Abstract: Two factors which seem to have a significant role in schizophrenia are infection and temperature. Evidence is presented that the schizophrenic population may be part of a sub-population which has preferential resistance to epidemic infection. This characteristic alone may not be responsible for vulnerability to schizophrenia. Part at least of the genetic predisposition to schizophrenia may lie in an abnormal response to hormonal disturbances in the intrauterine environment which may result from prenatal viral infection; this abnormal response may cause neurodevelopmental damage. Then in effect the vulnerability of some to schizophrenia will be the cost of population survival in epidemics. Dopamine is involved in central thermoregulation, and may be involved in response to infection. In two inbred mouse strains, one virus-resistant and the other virus-susceptible, there is also a difference in core body temperature response to dopamine. Because of the connection of dopamine sensitivity, temperature and resistance to infection the paired mouse strains are suggested as an animal model for studies relevant to schizophrenia.
Gov't Doc #: 8398951
Journal: Schizophrenia research
Type: Journal Article
Subjects: Animals
Body Temperature Regulation.physiology
Disease Models, Animal
Diseases in Twins
Gene Pool
Limbic System.physiopathology
Mice, Inbred Strains
Prenatal Exposure Delayed Effects
Risk Factors
Schizophrenic Psychology
Appears in Collections:Journal articles

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