Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/13350
Title: | Schizophrenia, infection and temperature. An animal model for investigating their interrelationships. | Austin Authors: | Rubinstein, G | Affiliation: | University of Melbourne Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Aug-1993 | Publication information: | Schizophrenia Research; 10(2): 95-102 | Abstract: | Two factors which seem to have a significant role in schizophrenia are infection and temperature. Evidence is presented that the schizophrenic population may be part of a sub-population which has preferential resistance to epidemic infection. This characteristic alone may not be responsible for vulnerability to schizophrenia. Part at least of the genetic predisposition to schizophrenia may lie in an abnormal response to hormonal disturbances in the intrauterine environment which may result from prenatal viral infection; this abnormal response may cause neurodevelopmental damage. Then in effect the vulnerability of some to schizophrenia will be the cost of population survival in epidemics. Dopamine is involved in central thermoregulation, and may be involved in response to infection. In two inbred mouse strains, one virus-resistant and the other virus-susceptible, there is also a difference in core body temperature response to dopamine. Because of the connection of dopamine sensitivity, temperature and resistance to infection the paired mouse strains are suggested as an animal model for studies relevant to schizophrenia. | Gov't Doc #: | 8398951 | URI: | http://ahro.austin.org.au/austinjspui/handle/1/13350 | Journal: | Schizophrenia research | URL: | https://pubmed.ncbi.nlm.nih.gov/8398951 | Type: | Journal Article | Subjects: | Animals Body Temperature Regulation.physiology Disease Models, Animal Diseases in Twins Dopamine.physiology Female Gene Pool Humans Infection.complications.physiopathology Limbic System.physiopathology Mice Mice, Inbred Strains Pregnancy Prenatal Exposure Delayed Effects Risk Factors Schizophrenia.etiology.genetics.physiopathology Schizophrenic Psychology |
Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.