Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13235
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dc.contributor.authorRolls, K Aen
dc.contributor.authorPhillips, P Aen
dc.contributor.authorAldred, K Len
dc.contributor.authorHardy, Kenneth Johnen
dc.date.accessioned2015-05-16T03:03:09Z
dc.date.available2015-05-16T03:03:09Z
dc.date.issued1994-03-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 21(3): 227-30en
dc.identifier.govdoc8076427en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13235en
dc.description.abstract1. Since plasma renin activity is increased in cyclosporin A (CsA)-induced hypertension in the rat, the role of the vascular renin-angiotensin system (RAS) in CsA-induced hypertension was investigated in rat mesenteric resistance vessels. 2. Female Wistar rats received CsA (10 mg/kg per day, s.c.) or vehicle for 30 days. CsA treatment increased tail-cuff systolic blood pressure (CsA treated 135 +/- 3 mmHg vs control 125 +/- 1 mmHg, P < 0.0001). 3. Mesenteric resistance arteries (200-300 microns) were isolated and mounted in a microvessel myograph. Concentration-response curves to tetradecapeptide renin substrate (10(-11)-10(-6) mol/L), angiotensin I (10(-11)-10(-6) mol/L) and angiotensin II (10(-12)-10(-6) mol/L) showed no differences between CsA-treated and control groups. 4. Mesenteric vascular angiotensin-converting enzyme (ACE) characteristics were determined by radioligand binding. There were no differences in the content or affinity of ACE between CsA-treated and control rats. 5. These results suggest that the mesenteric vascular RAS does not play a major role in CsA-induced hypertension in the rat.en
dc.language.isoenen
dc.subject.otherAngiotensin I.pharmacologyen
dc.subject.otherAngiotensin II.pharmacologyen
dc.subject.otherAngiotensinogen.analogs & derivatives.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effects.physiologyen
dc.subject.otherCyclosporine.toxicityen
dc.subject.otherFemaleen
dc.subject.otherHypertension.chemically induced.physiopathologyen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMesenteric Arteries.drug effects.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.subject.otherRenin-Angiotensin System.drug effects.physiologyen
dc.subject.otherSensitivity and Specificityen
dc.subject.otherVascular Resistance.drug effects.physiologyen
dc.subject.otherVasoconstriction.drug effects.physiologyen
dc.titleVasoconstrictor responses to components of the renin-angiotensin system in cyclosporin-induced hypertension in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages227-30en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8076427en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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