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Title: Vasoconstrictor responses to components of the renin-angiotensin system in cyclosporin-induced hypertension in the rat.
Austin Authors: Rolls, K A;Phillips, P A;Aldred, K L;Hardy, Kenneth John
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1994
Publication information: Clinical and Experimental Pharmacology & Physiology; 21(3): 227-30
Abstract: 1. Since plasma renin activity is increased in cyclosporin A (CsA)-induced hypertension in the rat, the role of the vascular renin-angiotensin system (RAS) in CsA-induced hypertension was investigated in rat mesenteric resistance vessels. 2. Female Wistar rats received CsA (10 mg/kg per day, s.c.) or vehicle for 30 days. CsA treatment increased tail-cuff systolic blood pressure (CsA treated 135 +/- 3 mmHg vs control 125 +/- 1 mmHg, P < 0.0001). 3. Mesenteric resistance arteries (200-300 microns) were isolated and mounted in a microvessel myograph. Concentration-response curves to tetradecapeptide renin substrate (10(-11)-10(-6) mol/L), angiotensin I (10(-11)-10(-6) mol/L) and angiotensin II (10(-12)-10(-6) mol/L) showed no differences between CsA-treated and control groups. 4. Mesenteric vascular angiotensin-converting enzyme (ACE) characteristics were determined by radioligand binding. There were no differences in the content or affinity of ACE between CsA-treated and control rats. 5. These results suggest that the mesenteric vascular RAS does not play a major role in CsA-induced hypertension in the rat.
Gov't Doc #: 8076427
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Angiotensin I.pharmacology
Angiotensin II.pharmacology
Angiotensinogen.analogs & derivatives.pharmacology
Blood Pressure.drug effects.physiology
Hypertension.chemically induced.physiopathology
In Vitro Techniques
Mesenteric Arteries.drug effects.physiology
Rats, Wistar
Renin-Angiotensin System.drug effects.physiology
Sensitivity and Specificity
Vascular Resistance.drug effects.physiology
Vasoconstriction.drug effects.physiology
Appears in Collections:Journal articles

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