Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13195
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSavige, Judy Aen
dc.contributor.authorChang, Len
dc.contributor.authorSmith, C Len
dc.contributor.authorDuggan, J Cen
dc.date.accessioned2015-05-16T02:59:20Z
dc.date.available2015-05-16T02:59:20Z
dc.date.issued1994-06-01en
dc.identifier.citationAustralian and New Zealand Journal of Medicine; 24(3): 282-7en
dc.identifier.govdoc7980211en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13195en
dc.description.abstractAnti-neutrophil cytoplasmic antibodies (ANCA) are typically associated with small vessel vasculitides. They are also found in situations where other autoantibodies are common, sometimes after infections and possibly in individuals who have received multiple blood transfusions.The aim of this study was to determine the incidence of ANCA in a variety of haematological disorders, where these predisposing factors may be at work.Sera from patients with myelodysplasia (n = 26), acute myeloid leukaemia (AML) (n = 3), and myeloproliferative (n = 25) or lymphoproliferative syndromes (n = 16) were screened for ANCA using a crude neutrophil cytoplasmic extract ELISA and indirect immunofluorescent examination of normal peripheral blood neutrophils. Positive results were confirmed by ELISAs for anti-proteinase 3, anti-myeloperoxidase or anti-elastase antibodies.ANCA were demonstrated in two patients with myelodysplasia, both with chronic myelomonocytic leukaemia and greater than 5% blasts in the bone marrow. Both of these individuals were infected at the time that ANCA were demonstrated and other autoantibodies were present. One of these individuals had never had evidence of any vasculitis; the other probably developed myelodysplasia after treatment with cyclophosphamide for Wegener's granulomatosis. ANCA were demonstrated in one individual with AML secondary to myelodysplasia. ANCA were also found in a patient with lymphoma in whom autoantibodies against red cells and platelets were already noted. ANCA were demonstrated in one further individual with lymphomatoid granulomatosis, a condition that resembles Wegener's granulomatosis clinically and histologically, but which is treated as a lymphoma. No ANCA were present in any of the patients with myeloproliferative syndromes.ANCA probably occur secondary to immune dysregulation in myelodysplasia and the lymphoproliferative conditions and they are not necessarily associated with the presence of a vasculitis.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAntibodies, Antineutrophil Cytoplasmicen
dc.subject.otherAutoantibodies.analysisen
dc.subject.otherBiological Markers.analysisen
dc.subject.otherEnzyme-Linked Immunosorbent Assayen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLeukemia, Myeloid.immunologyen
dc.subject.otherLymphoproliferative Disorders.immunologyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMyelodysplastic Syndromes.immunologyen
dc.subject.otherMyeloproliferative Disorders.immunologyen
dc.titleAnti-neutrophil cytoplasmic antibodies (ANCA) in myelodysplasia and other haematological disorders.en
dc.typeJournal Articleen
dc.identifier.journaltitleAustralian and New Zealand Journal of Medicineen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, Melbourne, Victoria, Australiaen
dc.description.pages282-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7980211en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

6
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.