Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13172
Title: Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes.
Austin Authors: Komers, R;Allen, Terri J;Cooper, Mark E
Affiliation: Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital, Victoria, Australia
Issue Date: 1-Oct-1994
Publication information: Diabetes; 43(10): 1190-7
Abstract: To evaluate the role of nitric oxide (NO) in diabetic hyperfiltration, renal hemodynamic changes and changes in urinary excretion of NO2/NO3 in response to the NO inhibitor nitro-L-arginine methyl ester (L-NAME) and the NO-donating agent glyceryl trinitrate (GTN) were investigated in conscious streptozocin-induced diabetic (D) and age-matched control (C) rats. In all experiments, D rats demonstrated increased glomerular filtration rate (GFR), renal plasma flow (RPF), polyuria, and an increased urinary sodium excretion when compared with C rats. An intravenous bolus of low-dose L-NAME (1 mg/kg body wt) increased modestly systolic blood pressure (sBP) in C rats but had no effect on sBP in D rats. L-NAME induced a marked decrease in GFR and RPF in D rats with no change in filtration fraction (FF). In C rats, no change in GFR was observed, and RPF decreased, resulting in a rise in FF. A supramaximal dose of L-NAME (10 mg/kg body wt) increased sBP in C and D rats to a similar degree. With high-dose L-NAME, GFR decreased in D but not in C rats. There was a greater decrease in RPF in D rats when compared with C animals. An intravenous infusion of GTN induced a modest decrease in sBP in both C and D rats (P < 0.01). There were no changes in GFR and RPF in D rats, but in the C group, GTN increased RPF (P < 0.05) with a tendency for a rise in GFR (P = 0.09). Basal urinary NO2/NO3 excretion was increased in D rats in all experiments.(ABSTRACT TRUNCATED AT 250 WORDS)
Gov't Doc #: 7926287
URI: https://ahro.austin.org.au/austinjspui/handle/1/13172
Journal: Diabetes
URL: https://pubmed.ncbi.nlm.nih.gov/7926287
Type: Journal Article
Subjects: Animals
Arginine.analogs & derivatives.pharmacology
Blood Pressure.drug effects
Diabetes Mellitus, Experimental.physiopathology
Diabetic Nephropathies.physiopathology
Dose-Response Relationship, Drug
Glomerular Filtration Rate.drug effects
Hemodynamics.drug effects
Kidney.blood supply
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide.physiology
Nitroglycerin.pharmacology
Rats
Rats, Sprague-Dawley
Reference Values
Regional Blood Flow.drug effects
Renal Circulation.drug effects
Appears in Collections:Journal articles

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