Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13146
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dc.contributor.authorO'Shea, R Den
dc.contributor.authorGundlach, Andrew Len
dc.date.accessioned2015-05-16T02:56:02Z
dc.date.available2015-05-16T02:56:02Z
dc.date.issued1994-10-27en
dc.identifier.citationNeuroreport; 5(16): 2113-6en
dc.identifier.govdoc7865757en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13146en
dc.description.abstractHypothalamic neuropeptide Y (NPY) and 5-hydroxytryptamine (5-HT) may interact to regulate food intake. This study investigated the effects of the 5-HT reuptake blocker and secretagogue D-fenfluramine (D-FEN) on preproNPY mRNA abundance in the hypothalamic arcuate nucleus (ARC) of free-feeding and food-deprived (FD) rats in two treatment regimens. ARC preproNPY mRNA levels were significantly increased in FD rats, to the same extent as in combined FD/D-FEN animals. D-FEN treatments producing different-sized reductions in food intake (and body weight) produced corresponding changes in ARC preproNPY mRNA abundance. These findings suggest that ARC preproNPY mRNA levels are not directly altered by D-FEN, and that D-FEN-induced anorexia does not involve effects on the hypothalamic NPY system at the level of NPY gene transcription.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherArcuate Nucleus of Hypothalamus.drug effects.metabolismen
dc.subject.otherBody Weight.drug effectsen
dc.subject.otherEating.drug effectsen
dc.subject.otherFenfluramine.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherNeuropeptide Y.geneticsen
dc.subject.otherProtein Precursors.geneticsen
dc.subject.otherRNA, Messenger.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Sprague-Dawleyen
dc.titleLack of direct action of D-fenfluramine on arcuate preproNPY mRNA levels in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroreporten
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin and Heidelberg Repatriation Hospitals, Victoria, Australiaen
dc.description.pages2113-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7865757en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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