Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13146
Title: Lack of direct action of D-fenfluramine on arcuate preproNPY mRNA levels in the rat.
Austin Authors: O'Shea, R D;Gundlach, Andrew L
Affiliation: University of Melbourne, Department of Medicine, Austin and Heidelberg Repatriation Hospitals, Victoria, Australia
Issue Date: 27-Oct-1994
Publication information: Neuroreport; 5(16): 2113-6
Abstract: Hypothalamic neuropeptide Y (NPY) and 5-hydroxytryptamine (5-HT) may interact to regulate food intake. This study investigated the effects of the 5-HT reuptake blocker and secretagogue D-fenfluramine (D-FEN) on preproNPY mRNA abundance in the hypothalamic arcuate nucleus (ARC) of free-feeding and food-deprived (FD) rats in two treatment regimens. ARC preproNPY mRNA levels were significantly increased in FD rats, to the same extent as in combined FD/D-FEN animals. D-FEN treatments producing different-sized reductions in food intake (and body weight) produced corresponding changes in ARC preproNPY mRNA abundance. These findings suggest that ARC preproNPY mRNA levels are not directly altered by D-FEN, and that D-FEN-induced anorexia does not involve effects on the hypothalamic NPY system at the level of NPY gene transcription.
Gov't Doc #: 7865757
URI: https://ahro.austin.org.au/austinjspui/handle/1/13146
Journal: Neuroreport
URL: https://pubmed.ncbi.nlm.nih.gov/7865757
Type: Journal Article
Subjects: Animals
Arcuate Nucleus of Hypothalamus.drug effects.metabolism
Body Weight.drug effects
Eating.drug effects
Fenfluramine.pharmacology
Male
Neuropeptide Y.genetics
Protein Precursors.genetics
RNA, Messenger.metabolism
Rats
Rats, Sprague-Dawley
Appears in Collections:Journal articles

Show full item record

Page view(s)

16
checked on Jun 19, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.