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Title: Lack of direct action of D-fenfluramine on arcuate preproNPY mRNA levels in the rat.
Austin Authors: O'Shea, R D;Gundlach, Andrew L
Affiliation: University of Melbourne, Department of Medicine, Austin and Heidelberg Repatriation Hospitals, Victoria, Australia
Issue Date: 27-Oct-1994
Publication information: Neuroreport; 5(16): 2113-6
Abstract: Hypothalamic neuropeptide Y (NPY) and 5-hydroxytryptamine (5-HT) may interact to regulate food intake. This study investigated the effects of the 5-HT reuptake blocker and secretagogue D-fenfluramine (D-FEN) on preproNPY mRNA abundance in the hypothalamic arcuate nucleus (ARC) of free-feeding and food-deprived (FD) rats in two treatment regimens. ARC preproNPY mRNA levels were significantly increased in FD rats, to the same extent as in combined FD/D-FEN animals. D-FEN treatments producing different-sized reductions in food intake (and body weight) produced corresponding changes in ARC preproNPY mRNA abundance. These findings suggest that ARC preproNPY mRNA levels are not directly altered by D-FEN, and that D-FEN-induced anorexia does not involve effects on the hypothalamic NPY system at the level of NPY gene transcription.
Gov't Doc #: 7865757
Journal: Neuroreport
Type: Journal Article
Subjects: Animals
Arcuate Nucleus of Hypothalamus.drug effects.metabolism
Body Weight.drug effects
Eating.drug effects
Neuropeptide Y.genetics
Protein Precursors.genetics
RNA, Messenger.metabolism
Rats, Sprague-Dawley
Appears in Collections:Journal articles

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