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Title: Platelet [3H]paroxetine binding in panic disorder.
Austin Authors: Maguire, K P;Norman, Trevor R ;Apostolopoulos, M;Judd, F K;Burrows, Graham D
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 21-Feb-1995
Publication information: Journal of Affective Disorders; 33(2): 117-22
Abstract: Platelet [3H]paroxetine binding was measured in 20 patients (14 females, six males) with panic disorder and 20 normal controls (14 females, six males). For patients with panic disorder, Bmax was 1987 +/- 1135 fmol/mg protein (mean +/- SD) compared with control Bmax values of 1626 +/- 611 fmol/mg protein. The mean Kd value for the patients was 0.076 +/- 0.056 nM and for the controls was 0.083 +/- 0.033 nM. ANCOVA indicated no significant effect of sex, diagnosis (panic disorder vs. normal controls) or season of sampling on either Kd or Bmax. The data provide no evidence for an abnormality of the platelet uptake mechanism in panic disorder.
Gov't Doc #: 7759659
Type: Journal Article
Subjects: Adult
Analysis of Variance
Binding Sites
Blood Platelets.metabolism
Panic Disorder.blood
Radioligand Assay
Tritium.diagnostic use
Appears in Collections:Journal articles

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