Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13100
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dc.contributor.authorKomersova, Ken
dc.contributor.authorRogerson, J Wen
dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorLim, T Cen
dc.contributor.authorBrown, Douglas Jen
dc.contributor.authorKrum, Henryen
dc.contributor.authorJackman, G Pen
dc.contributor.authorMurdoch, Ren
dc.contributor.authorLouis, William Jen
dc.date.accessioned2015-05-16T02:52:57Z
dc.date.available2015-05-16T02:52:57Z
dc.date.issued1995-02-01en
dc.identifier.citationBritish Journal of Clinical Pharmacology; 39(2): 207-9en
dc.identifier.govdoc7742166en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13100en
dc.description.abstractThe effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAnalysis of Varianceen
dc.subject.otherBenzopyrans.pharmacologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCromakalimen
dc.subject.otherHumansen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherMaleen
dc.subject.otherPotassium Channels.drug effectsen
dc.subject.otherPyrroles.pharmacologyen
dc.subject.otherSpinal Cord Injuries.physiopathologyen
dc.subject.otherUrinary Bladder, Neurogenic.physiopathologyen
dc.subject.otherUrodynamics.drug effectsen
dc.titleThe effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish journal of clinical pharmacologyen
dc.identifier.affiliationDepartment of Clinical Pharmacology and Therapeutics, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages207-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7742166en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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