Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/13100
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Komersova, K | en |
dc.contributor.author | Rogerson, J W | en |
dc.contributor.author | Conway, Elizabeth L | en |
dc.contributor.author | Lim, T C | en |
dc.contributor.author | Brown, Douglas J | en |
dc.contributor.author | Krum, Henry | en |
dc.contributor.author | Jackman, G P | en |
dc.contributor.author | Murdoch, R | en |
dc.contributor.author | Louis, William J | en |
dc.date.accessioned | 2015-05-16T02:52:57Z | |
dc.date.available | 2015-05-16T02:52:57Z | |
dc.date.issued | 1995-02-01 | en |
dc.identifier.citation | British Journal of Clinical Pharmacology; 39(2): 207-9 | en |
dc.identifier.govdoc | 7742166 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13100 | en |
dc.description.abstract | The effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically. | en |
dc.language.iso | en | en |
dc.subject.other | Adult | en |
dc.subject.other | Analysis of Variance | en |
dc.subject.other | Benzopyrans.pharmacology | en |
dc.subject.other | Blood Pressure.drug effects | en |
dc.subject.other | Cromakalim | en |
dc.subject.other | Humans | en |
dc.subject.other | Infusions, Intravenous | en |
dc.subject.other | Male | en |
dc.subject.other | Potassium Channels.drug effects | en |
dc.subject.other | Pyrroles.pharmacology | en |
dc.subject.other | Spinal Cord Injuries.physiopathology | en |
dc.subject.other | Urinary Bladder, Neurogenic.physiopathology | en |
dc.subject.other | Urodynamics.drug effects | en |
dc.title | The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | British journal of clinical pharmacology | en |
dc.identifier.affiliation | Department of Clinical Pharmacology and Therapeutics, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 207-9 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/7742166 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Louis, William J | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Clinical Pharmacology and Therapeutics | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.