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Title: The effect of levcromakalim (BRL 38227) on bladder function in patients with high spinal cord lesions.
Austin Authors: Komersova, K;Rogerson, J W;Conway, Elizabeth L;Lim, T C;Brown, Douglas J;Krum, Henry;Jackman, G P;Murdoch, R;Louis, William J 
Affiliation: Department of Clinical Pharmacology and Therapeutics, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Feb-1995
Publication information: British Journal of Clinical Pharmacology; 39(2): 207-9
Abstract: The effects of the potassium channel opener levcromakalim (BRL 38227) 7.5 micrograms kg-1 were examined on urodynamic variables and blood pressure during inflow and voiding cystometry in six high spinal cord lesion patients. Levcromakalim administration significantly increased the duration of bladder contraction (197 +/- 128 s to 267 +/- 167 s, P < 0.05) and also reduced blood pressure (126 +/- 13/67 +/- 9 mm Hg to 104 +/- 25/52 +/- 12 mm Hg) but was without effect on other urodynamic parameters. Because of concerns about hypotensive responses, further studies involving higher doses of levcromakalim should be considered only if the drug was administered intravesically.
Gov't Doc #: 7742166
Type: Journal Article
Subjects: Adult
Analysis of Variance
Blood Pressure.drug effects
Infusions, Intravenous
Potassium Channels.drug effects
Spinal Cord Injuries.physiopathology
Urinary Bladder, Neurogenic.physiopathology
Urodynamics.drug effects
Appears in Collections:Journal articles

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