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Title: Disseminated, multiclonal Epstein-Barr virus-associated lymphoproliferative disease in a patient with hematological and immunological anomalies. Molecular analysis correlates with morphological appearance.
Austin Authors: Armes, J E;Eades, S;Southey, M C;Ross, B C;Carapetis, J R;Chow, C W;Venter, D J
Affiliation: Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1995
Publication information: Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B; 4(1): 39-47
Abstract: We report a case of a 21-year-old woman with hematopoietic, immunological, and congenital dysmorphic abnormalities, who died following rapidly progressive, disseminated Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD). Polymerase chain reaction (PCR) amplification of formalin-fixed paraffin-embedded tissue showed differences in the clonality of each separate lymphoproliferative lesion examined, as determined by immunoglobulin heavy chain (IgH) gene rearrangement. PCR analysis also demonstrated that all lesions contained EBV genome. Since DNA had been extracted from paraffin blocks, a direct comparison of morphology and clonality could be made in each individual lesion. The evidence from this study indicates that the monoclonal tumors arose de novo in multiple sites and that the polyclonal background observed in some lesions reflected a substantial concomitant inflammatory response.
Gov't Doc #: 7735554
Journal: Diagnostic molecular pathology : the American journal of surgical pathology, part B
Type: Journal Article
Subjects: Blotting, Southern
Clone Cells
DNA, Viral.isolation & purification
Herpesviridae Infections.blood.immunology.pathology
Herpesvirus 4, Human.isolation & purification
Lymphoproliferative Disorders.blood.immunology.pathology.virology
Polymerase Chain Reaction
Tumor Virus Infections.blood.immunology.pathology
Appears in Collections:Journal articles

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