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https://ahro.austin.org.au/austinjspui/handle/1/13097| Title: | Interactions of angiotensin II with central catecholamines. | Austin Authors: | Jenkins, T A;Allen, A M;Chai, Syn Y;Mendelsohn, Frederick AO | Affiliation: | Department of Medicine, University of Melbourne, Austin Hospital Heidelberg, Victoria. | Issue Date: | 2-Jan-1995 | Publication information: | Clinical and Experimental Hypertension (new York, N.y. : 1993); 17(1-2): 267-80 | Abstract: | There is a large body of anatomical and functional evidence supporting an interaction between brain angiotensin and central catecholamine systems. Angiotensin II AT1 receptors have been identified on dopamine containing cells in the substantia nigra and striatum of human brain using receptor autoradiography. Using in vivo microdialysis we have demonstrated that locally administered angiotensin II stimulates dopamine release from the striatum of conscious rats. Since some angiotensin receptor antagonists and angiotensin converting enzyme inhibitors can cross the blood brain barrier it is possible that they interact with the brain catecholaminergic systems. | Gov't Doc #: | 7735274 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13097 | Journal: | Clinical and experimental hypertension (New York, N.Y. : 1993) | URL: | https://pubmed.ncbi.nlm.nih.gov/7735274 | Type: | Journal Article | Subjects: | Angiotensin II.physiology Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors.pharmacology Animals Biphenyl Compounds.pharmacology Brain.drug effects.physiology Catecholamines.physiology Dopamine.physiology Humans Imidazoles.pharmacology Losartan Rats Tetrazoles.pharmacology |
| Appears in Collections: | Journal articles |
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