Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13095
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dc.contributor.authorRumble, J Ren
dc.contributor.authorDoyle, A Een
dc.contributor.authorCooper, Mark Een
dc.date.accessioned2015-05-16T02:52:37Z
dc.date.available2015-05-16T02:52:37Z
dc.date.issued1995-01-01en
dc.identifier.citationAmerican Journal of Hypertension; 8(1): 53-7en
dc.identifier.govdoc7734098en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/13095en
dc.description.abstractThe aim of this study was to compare the renal effects of angiotensin converting enzyme (ACE) inhibition with calcium channel blockade in a model combining genetic hypertension with diabetes. Streptozotocin diabetes was induced in spontaneously hypertensive rats (SHR). The animals were then randomized to receive no treatment, the ACE inhibitor, perindopril, or the dihydropyridine calcium antagonist lacidipine. Body weight, systolic blood pressure, glycemic control, renal function, and albumin excretion rate (AER) were assessed serially over the 32-week study period. At week 32 the animals were killed and glomerular volume was measured. Both antihypertensive regimens significantly reduced systolic blood pressure in diabetic SHR. There was no significant difference in glycemic control, serum creatinine, or glomerular filtration rate among the three groups at week 32. The ACE inhibitor perindopril significantly reduced AER and glomerular hypertrophy over the 32 weeks, whereas the calcium antagonist lacidipine failed to reduce AER or glomerular hypertrophy. Thus, in contrast to the effects of ACE inhibition, calcium channel blockade with lacidipine, despite significantly reducing blood pressure, failed to reduce renal injury in this model. These results support the hypothesis that antihypertensive regimens may differ in their capacity to protect the diabetic kidney, despite similar effects on systemic blood pressure.en
dc.language.isoenen
dc.subject.otherAlbuminuria.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherBlood Glucose.drug effectsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherBody Weighten
dc.subject.otherDiabetes Mellitus, Experimental.complications.drug therapy.physiopathologyen
dc.subject.otherDihydropyridines.pharmacologyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherHypertension.complications.drug therapy.physiopathologyen
dc.subject.otherIndoles.pharmacologyen
dc.subject.otherKidney Diseases.drug therapy.etiology.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherPerindoprilen
dc.subject.otherRandom Allocationen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRenin.blood.drug effectsen
dc.titleComparison of effects of ACE inhibition with calcium channel blockade on renal disease in a model combining genetic hypertension and diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Hypertensionen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Heidelberg Repatriation/Austin Hospitals, Australiaen
dc.identifier.doi10.1016/0895-7061(94)00165-8en
dc.description.pages53-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/7734098en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
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