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Title: Lupus anticoagulant in anti-neutrophil cytoplasmic antibody-associated polyarteritis.
Austin Authors: Cohney, S;Savige, Judy A;Stewart, M R
Affiliation: Renal Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1995
Publication information: American Journal of Nephrology; 15(2): 157-60
Abstract: Lupus anticoagulant has been described in association with many autoimmune disorders. Here we describe its occurrence in a patient with ANCA-associated microscopic polyarteritis with medium vessel involvement. A 62-year-old man presented with mononeuritis multiplex and abdominal pain and was demonstrated to have multiple aneurysms on visceral angiography, consistent with the diagnosis of medium vessel vasculitis or classical polyarteritis nodosa. In addition he had active tuberculosis. He developed a deep venous thrombosis at this admission and, on one occasion, had a prolonged APTT but this was not confirmed to be due to a lupus anticoagulant. Two years later when the patient was readmitted with fevers, headaches and nasal discharge, both ANCA and a lupus anticoagulant were demonstrated in his serum, although there was no evidence of a venous thrombosis. Six months later the patient was demonstrated for the first time to have dysmorphic urinary RBC consistent with glomerular bleeding; at the same time he developed a deep venous thrombosis. ANCA was still present, but the lupus anticoagulant could not be detected. The patient was treated with cyclophosphamide and prednisolone and a Greenfield filter inserted into his inferior vena cava.
Gov't Doc #: 7733154
Journal: American journal of nephrology
Type: Journal Article
Subjects: Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide.therapeutic use
Lupus Coagulation Inhibitor.analysis
Middle Aged
Polyarteritis Nodosa.complications.drug therapy.immunology
Prednisolone.therapeutic use
Tuberculosis, Pulmonary.complications
Appears in Collections:Journal articles

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