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Title: End-organ involvement and calcium antagonist therapy: animal studies.
Austin Authors: Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1994
Publication information: Journal of Cardiovascular Pharmacology; 24 Suppl A(): S12-7
Abstract: Hypertension is a complex disease, the treatment of which should not only lower systolic and diastolic blood pressure but also attenuate the secondary consequences of the disease. These include vascular injury (including atherosclerosis), stroke, left ventricular hypertrophy, and renal damage. To establish whether the long-acting, vascular-selective calcium antagonist amlodipine attenuates some of these secondary consequences of hypertension, 5-week-old stroke-prone hypertensive and 8-week-old spontaneously hypertensive rats were treated (orally) with 5 mg/kg/day and 10 mg/kg/day amlodipine, respectively, for 30 weeks. The treatment resulted in a significant lowering of systolic blood pressure, accompanied by reduced cardiac hypertrophy and prolonged survival. Evidence for a protective effect of amlodipine on the vasculature was obtained by treating cholesterol-fed rabbits with 1-5 mg/kg/body weight/day. This resulted in a reduction in vascular Ca2+ overloading and a reduced incidence of sudanophilic lesion formation. Protection against ischemia-induced changes in the myocardium included a reduction in the ischemia-induced externalization of endothelin-1 binding sites.
Gov't Doc #: 7603072
Journal: Journal of Cardiovascular Pharmacology
Type: Journal Article
Subjects: Administration, Oral
Amlodipine.administration & dosage.pharmacology.therapeutic use
Aorta, Thoracic.drug effects.metabolism.pathology
Arteriosclerosis.etiology.prevention & control
Binding Sites
Blood Pressure.drug effects
Cardiomegaly.mortality.prevention & control
Cholesterol, Dietary.administration & dosage
Disease Models, Animal
Hypertension.complications.drug therapy.mortality
Myocardial Ischemia.drug therapy.metabolism
Myocardial Reperfusion Injury.drug therapy.metabolism
Rats, Inbred SHR
Rats, Inbred WKY
Appears in Collections:Journal articles

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