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dc.contributor.authorAngus, Peter Wen
dc.contributor.authorNg, C Yen
dc.contributor.authorGhabrial, Hanyen
dc.contributor.authorMorgan, Denis Jen
dc.contributor.authorSmallwood, R Aen
dc.identifier.citationDrug Metabolism and Disposition: the Biological Fate of Chemicals; 23(4): 485-9en
dc.description.abstractThe effect of heart failure on the hepatic elimination of low-clearance drugs has not been clearly defined. We investigated the effect of left ventricular failure on theophylline clearance in rats. Cardiovascular function and theophylline pharmacokinetics were studied in conscious rats 6-8 weeks after left anterior descending coronary artery ligation. Rats with infarcts involving > 35% of the left ventricle (N = 9) had severe left ventricular failure, and, compared with control rats (N = 9), had reduced cardiac output (97.3 +/- 18.2 vs. 132 +/- 26 ml/min; p < 0.05), reduced mean arterial blood pressure (86 +/- 20 vs. 109 +/- 16 mm Hg; p < 0.05), markedly elevated left ventricular end-diastolic pressure (25.9 +/- 13.6 vs. 10.6 +/- 3.9 mm Hg; p < 0.01), and increased lung weight. There was also an increase in central venous pressure (6.44 +/- 2.60 vs. 3.67 +/- 2.60 mm Hg; p < 0.05), but no evidence of hepatic congestion, as judged by liver weights (14.7 +/- 1.5 vs. 15.3 +/- 1.3 g) and liver histology. However, total hepatic blood flow, total hepatic oxygen delivery, and theophylline clearance were found to be similar in both groups (1.66 +/- 0.30 vs. 1.75 +/- 0.38 ml/min/g liver weight; 12.4 +/- 1.8 vs. 13.3 +/- 3.7 mumol/min/g liver weight and 0.451 +/- 0.097 vs. 0.438 +/- 0.079 ml/min/100 g body weight), respectively. Taking the infarct group as a whole, total hepatic oxygen delivery was linearly correlated to theophylline clearance (r = 0.66, p < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.subject.otherCentral Venous Pressure.physiologyen
dc.subject.otherMyocardial Infarction.metabolism.pathologyen
dc.subject.otherOrgan Size.physiologyen
dc.subject.otherRats, Sprague-Dawleyen
dc.subject.otherVentricular Dysfunction, Left.metabolism.physiopathologyen
dc.subject.otherVentricular Function, Left.physiologyen
dc.titleEffects of chronic left ventricular failure on hepatic oxygenation and theophylline elimination in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleDrug metabolism and disposition: the biological fate of chemicalsen
dc.identifier.affiliationGastroenterology Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en- Liver Transplant Unit- and Hepatology-
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