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Title: Activity-linked alterations in cholecystokininB receptor messenger RNA levels in magnocellular hypothalamic neurones by food and water deprivation in the rat.
Austin Authors: O'Shea, R D;Gundlach, Andrew L
Affiliation: University of Melbourne Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 21-Jul-1995
Publication information: Neuroscience Letters; 194(3): 189-92
Abstract: CholecystokininB receptors in the hypothalamic supraoptic and paraventricular nuclei may be involved in the regulation of appetite and neuroendocrine function. In situ hybridisation was used to determine levels of mRNA encoding cholecystokininB receptors in these nuclei in normal rats and rats deprived of food, water or both food and water for 4 days. Food deprivation produced no significant change in the level of cholecystokininB mRNA in these hypothalamic nuclei. Water deprivation increased cholecystokininB mRNA levels (412 +/- 16% and 1009 +/- 69% of control for supraoptic and paraventricular nuclei, respectively) while combined food and water deprivation resulted in significantly smaller increases in these nuclei (193 +/- 20% and 303 +/- 44% of control). Increases in the paraventricular nucleus were most prominent in magnocellular (especially oxytocin-rich) subdivisions of this nucleus. These selective alterations are consistent with similar changes in cholecystokinin receptor density in these hypothalamic nuclei, and support an autocrine/paracrine role for cholecystokinin in the regulation of appetite and endocrine function via effects on hypothalamic oxytocinergic activity.
Gov't Doc #: 7478235
Type: Journal Article
Subjects: Animals
Food Deprivation
In Situ Hybridization
RNA, Messenger.biosynthesis.metabolism
Rats, Sprague-Dawley
Receptors, Cholecystokinin.biosynthesis.genetics.metabolism
Water Deprivation
Appears in Collections:Journal articles

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