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Title: The psychomotor effects of single and repeated doses of hypnotic benzodiazepines.
Austin Authors: Stanley, R O;Tiller, J W;Adrian, J
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Oct-1987
Publication information: International Clinical Psychopharmacology; 2(4): 317-23
Abstract: Benzodiazepine hypnotics are used for short periods in low doses in healthy people when stressed and in patients with insomnia. This study examined psychomotor impairment in healthy young males and females after 1 and 7 nights of flunitrazepam (1 mg), nitrazepam (2.5 mg) and temazepam (10 mg). There were substantial inter-individual variations. Results showed that no drug significantly affected psychomotor performance at these doses after single or repeated administration. The number and severity of side-effects were significantly greater after the first night with temazepam and 7 nights with nitrazepam, although this may reflect a statistical artefact rather than a significant clinical finding. The difficulties in performing adequately controlled psychopharmacological studies at low doses are highlighted. Given the large intra- and inter-subject variances, small drug effects would necessitate large sample sizes (21 to 600 subjects at the 95% level of chance of detection) depending on the variable. The study suggests there is minimal impairment with low dose hypnotic drugs and a need to individualize treatment.
Gov't Doc #: 3693871
Type: Journal Article
Subjects: Adult
Benzodiazepines.administration & dosage.adverse effects.pharmacology
Flunitrazepam.administration & dosage.adverse effects.pharmacology
Nitrazepam.administration & dosage.adverse effects.pharmacology
Psychomotor Disorders.chemically induced
Psychomotor Performance.drug effects
Temazepam.administration & dosage.adverse effects.pharmacology
Appears in Collections:Journal articles

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