Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12995
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dc.contributor.authorMason, R Ten
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorZajac, J Den
dc.contributor.authorFletcher, A Een
dc.contributor.authorHardy, Kenneth Johnen
dc.contributor.authorMartin, T Jen
dc.date.accessioned2015-05-16T02:45:57Z
dc.date.available2015-05-16T02:45:57Z
dc.date.issued1986-12-01en
dc.identifier.citationClinical Endocrinology; 25(6): 675-85en
dc.identifier.govdoc3498561en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12995en
dc.description.abstractCalcitonin gene-related peptide (CGRP) is a recently discovered peptide whose existence was first predicted following sequence analysis of the rat calcitonin gene. In the present study, plasma levels of CGRP were measured in patients with medullary thyroid carcinoma, both basally and following calcium or pentagastrin stimulation. Using a sensitive radioimmunoassay for CGRP, 19 of 21 patients with medullary thyroid carcinoma had elevated plasma levels of immunoreactive CGRP (median value 114 pmol/l) while 23 normal subjects had plasma CGRP levels below the detection limit of the assay (less than 10 pmol/l). Calcium or pentagastrin infusion in medullary thyroid carcinoma patients were potent stimuli to CGRP release, increasing plasma levels two- to five-fold. Chromatographic characterization using high pressure liquid chromatography of the CGRP immunoreactivity in plasma from two patients with medullary carcinoma of the thyroid demonstrated the presence of two molecular forms, neither of which co-eluted with synthetic human CGRP. The role of CGRP in the pathophysiology of medullary thyroid carcinoma is not clear but it may contribute to some of the clinical features associated with the disease. Furthermore, measurement of CGRP in conjunction with calcitonin could help in determining the prognosis of these patients.en
dc.language.isoenen
dc.subject.otherCalcitonin.blooden
dc.subject.otherCalcitonin Gene-Related Peptideen
dc.subject.otherCalcium.pharmacologyen
dc.subject.otherCarcinoma.physiopathologyen
dc.subject.otherChromatography, High Pressure Liquiden
dc.subject.otherHumansen
dc.subject.otherNeuropeptides.blooden
dc.subject.otherPentagastrin.pharmacologyen
dc.subject.otherRadioimmunoassayen
dc.subject.otherThyroid Neoplasms.physiopathologyen
dc.titleBasal and stimulated release of calcitonin gene-related peptide (CGRP) in patients with medullary thyroid carcinoma.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Endocrinologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Surgery, Austin Hospital, Australiaen
dc.description.pages675-85en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3498561en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
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