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Title: Extraction of neurotensin by the liver.
Austin Authors: Brook, C W;Shulkes, Arthur;Sewell, Richard B;Smallwood, R A
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 1-Oct-1987
Publication information: Clinical and Experimental Pharmacology & Physiology; 14(10): 791-5
Abstract: 1. Neurotensin is released from the intestine into the portal circulation and to exert a systemic effect it must traverse the liver intact. 2. The role of the liver in neurotensin clearance was examined using the isolated perfused rat liver preparation. Two concentrations of neurotensin were used to determine the extraction capacity of the liver. 3. Approximately 10% of the added neurotensin (with either dose) was extracted in a single pass through the liver. This extraction rate was low when compared to previous studies with cholecystokinin (60% extraction in a single pass) and vasoactive intestinal peptide (100%). 4. It is concluded that there is a small but high capacity for direct extraction of neurotensin. This low direct extraction percentage supports our previous contention that the major influence of the liver on the metabolism of neurotensin is by the release of neurotensin degrading peptidases into the circulation.
Gov't Doc #: 3442950
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Animals
In Vitro Techniques
Rats, Inbred Strains
Appears in Collections:Journal articles

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