Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12992
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dc.contributor.authorBrook, C Wen
dc.contributor.authorShulkes, Arthuren
dc.contributor.authorSewell, Richard Ben
dc.contributor.authorSmallwood, R Aen
dc.date.accessioned2015-05-16T02:45:45Z
dc.date.available2015-05-16T02:45:45Z
dc.date.issued1987-10-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 14(10): 791-5en
dc.identifier.govdoc3442950en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12992en
dc.description.abstract1. Neurotensin is released from the intestine into the portal circulation and to exert a systemic effect it must traverse the liver intact. 2. The role of the liver in neurotensin clearance was examined using the isolated perfused rat liver preparation. Two concentrations of neurotensin were used to determine the extraction capacity of the liver. 3. Approximately 10% of the added neurotensin (with either dose) was extracted in a single pass through the liver. This extraction rate was low when compared to previous studies with cholecystokinin (60% extraction in a single pass) and vasoactive intestinal peptide (100%). 4. It is concluded that there is a small but high capacity for direct extraction of neurotensin. This low direct extraction percentage supports our previous contention that the major influence of the liver on the metabolism of neurotensin is by the release of neurotensin degrading peptidases into the circulation.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherFemaleen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherLiver.metabolismen
dc.subject.otherNeurotensin.metabolismen
dc.subject.otherPerfusionen
dc.subject.otherRadioimmunoassayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleExtraction of neurotensin by the liver.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.description.pages791-5en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3442950en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
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