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Title: Regional brain concentrations of cholecystokinin in the rat: the effects of kindled and non-kindled seizures.
Austin Authors: Harris, Q L;Lewis, S J;Shulkes, Arthur;Vajda, F J;Jarrott, B
Affiliation: University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 1-May-1988
Publication information: Neuropharmacology; 27(5): 547-50
Abstract: In an attempt to understand the neurochemical basis of kindling, this study investigated the effects on brain cholecystokinin (CCK) of amygdaloid kindled and non-kindled seizures. Thirteen brain regions were examined in rats sacrificed either 24 hr or 3 weeks after the last kindled seizure, or 24 hr after a suprathreshold stimulation-induced (non-kindled) seizure; and in sham kindled rats. There were no significant differences in CCK immunoreactivity between any of these groups. These results do not confirm a previous report of an increase in CCK in the hippocampus following amygdaloid kindling in the rat.
Gov't Doc #: 3393271
Type: Journal Article
Subjects: Animals
Brain.anatomy & histology
Brain Chemistry.drug effects
Kindling, Neurologic
Organ Size
Rats, Inbred Strains
Appears in Collections:Journal articles

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