Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12976
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dc.contributor.authorMendelsohn, Frederick AOen
dc.contributor.authorAllen, A Men
dc.contributor.authorClevers, Jen
dc.contributor.authorDenton, D Aen
dc.contributor.authorTarjan, Een
dc.contributor.authorMcKinley, M Jen
dc.date.accessioned2015-05-16T02:44:40Z
dc.date.available2015-05-16T02:44:40Z
dc.date.issued1988-04-15en
dc.identifier.citationThe Journal of Comparative Neurology; 270(3): 372-84en
dc.identifier.govdoc3372742en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12976en
dc.description.abstractBinding of 125I-[Sar1,Ile8] angiotensin II (AII) to sections of brains from both wild and laboratory rabbits was determined by in vitro autoradiography. In the forebrain, specific high density binding was observed in the olfactory bulb, organum vasculosum of the lamina terminalis (OVLT), subfornical organ, median eminence, lateral septum, median preoptic nucleus and hypothalamic paraventricular, supraoptic and arcuate nuclei. In the midbrain, binding of the radioligand was observed in the interpeduncular and parabrachial nuclei, in the locus coeruleus, and ventrolateral pons. In the hind brain, there was dense binding of 125I-[Sar1,Ile8] AII to the nucleus of the solitary tract (NTS) and to both rostral and caudal parts of the reticular formation of the ventrolateral medulla oblongata. Weaker specific binding of the radioligand to the molecular layer of the cerebellum, to the nucleus of the spinal trigeminal tract, dorsal motor nucleus of the vagus, area postema, and to a band of tissue connecting the NTS to the ventrolateral medulla was also observed. Binding of the ligand to circumventricular organs such as the OVLT, subfornical organ, and median eminence suggests that these are sites in the brain of the rabbit at which blood-borne AII may exert influences on the central regulation of fluid balance and pituitary hormone secretion, although AII of neuronal origin could also act at these sites. Binding of the radioligand in several other brain regions suggests that angiotensin II of cerebral origin may be involved in a number of different aspects of brain function in the rabbit. The finding of dense binding in the NTS and ventrolateral medulla, which are involved in autonomic activity and are also sites of catecholamine-containing neurons, raises the possibility of angiotensin interaction with these neurons and involvement in autonomic function.en
dc.language.isoenen
dc.subject.otherAngiotensin IIen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherBrain.metabolismen
dc.subject.otherCerebellum.metabolismen
dc.subject.otherHypothalamus.metabolismen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMedulla Oblongata.metabolismen
dc.subject.otherMesencephalon.metabolismen
dc.subject.otherOlfactory Bulb.metabolismen
dc.subject.otherRabbits.metabolismen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.subject.otherSeptum Pellucidum.metabolismen
dc.subject.otherTissue Distributionen
dc.titleLocalization of angiotensin II receptor binding in rabbit brain by in vitro autoradiography.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of comparative neurologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Australiaen
dc.identifier.doi10.1002/cne.902700306en
dc.description.pages372-84en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3372742en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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