Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12955
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dc.contributor.authorLewis, S Jen
dc.contributor.authorRowe, Pen
dc.contributor.authorJarrott, Ben
dc.date.accessioned2015-05-16T02:43:16Z
dc.date.available2015-05-16T02:43:16Z
dc.date.issued1988-10-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 15(10): 773-80en
dc.identifier.govdoc3271181en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12955en
dc.description.abstract1. The concentrations of adrenaline and other catecholamines (noradrenaline and its major metabolite DHPG, dopamine and its major metabolite DOPAC) were measured in the hypothalamus and medulla oblongata of normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) which had received a continuous subcutaneous infusion of clonidine (10 micrograms/kg per h) for 10 days, and also in WKY and SHR rats which were killed 15-18 h after the cessation of the 10-day infusion. 2. The concentrations of adrenaline in the hypothalamus and medulla oblongata/pons of the clonidine treated WKY and SHR rats were not different from their respective controls. However, the adrenaline concentrations in the hypothalamus (but not the medulla oblongata) were significantly decreased in the post-infusion WKY and SHR. 3. These results suggest that hypothalamic adrenergic mechanisms may have a common involvement in the post-clonidine infusion syndromes displayed by the WKY and SHR strains.en
dc.language.isoenen
dc.subject.other3,4-Dihydroxyphenylacetic Acid.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherClonidine.adverse effectsen
dc.subject.otherDopamine.metabolismen
dc.subject.otherEpinephrine.metabolismen
dc.subject.otherFemaleen
dc.subject.otherHypothalamus.metabolismen
dc.subject.otherMedulla Oblongata.metabolismen
dc.subject.otherMethoxyhydroxyphenylglycol.analogs & derivatives.analysisen
dc.subject.otherNorepinephrine.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherSubstance Withdrawal Syndrome.metabolismen
dc.subject.otherTime Factorsen
dc.titleInvolvement of hypothalamic adrenaline in the clonidine withdrawal syndrome in normotensive and spontaneously hypertensive rats.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages773-80en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3271181en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
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