Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12947
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dc.contributor.authorMorgan, Denis Jen
dc.contributor.authorMihaly, G Wen
dc.contributor.authorCzuba, M Aen
dc.contributor.authorChing, M Sen
dc.contributor.authorHardy, Kenneth Johnen
dc.contributor.authorSmallwood, R Aen
dc.date.accessioned2015-05-16T02:42:43Z
dc.date.available2015-05-16T02:42:43Z
dc.date.issued1988-10-01en
dc.identifier.citationJournal of Pharmaceutical Sciences; 77(10): 835-7en
dc.identifier.govdoc3236224en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12947en
dc.description.abstractAccording to theory, for a drug of nonrestrictive, flow-limited clearance, a change during pregnancy of the unbound fraction (fu) of drug in maternal plasma should cause a change in steady-state unbound plasma drug concentration (Cu) in maternal plasma, which should also cause a change in fetal Cu. This theory was examined in 14 chronically cannulated, unanesthetized pregnant ewes in which 28 separate experiments were performed during the latter part of gestation. An initial bolus dose and 3-h constant rate infusion of propranolol were administered via the maternal jugular vein and steady-state maternal and fetal carotid arterial plasma total and unbound propranolol concentrations were measured. Fetal Cu (32 +/- 21 ng/mL) was significantly less than maternal Cu (78 +/- 52 ng/mL), due to previously demonstrated fetal hepatic extraction of propranolol. Notwithstanding fetal elimination, there was a significant correlation between fetal Cu and maternal Cu (r = 0.41, p less than 0.025). There was also a strong correlation between fetal Cu and the maternal unbound fraction of drug (fu; r = 0.75, p less than 0.001). We conclude that for propranolol, a drug of nonrestrictive, flow-limited clearance, changes in maternal fu can have a significant influence on fetal Cu, and therefore would be expected to influence the pharmacological effect of the drug in the fetus.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Proteins.metabolismen
dc.subject.otherFemaleen
dc.subject.otherFetal Blood.metabolismen
dc.subject.otherPregnancyen
dc.subject.otherPregnancy, Animal.blooden
dc.subject.otherPropranolol.blooden
dc.subject.otherProtein Bindingen
dc.subject.otherSheepen
dc.titleInfluence of maternal plasma protein binding on fetal unbound plasma concentration of propranolol in the pregnant ewe.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of pharmaceutical sciencesen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Australiaen
dc.description.pages835-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3236224en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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