Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12936
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dc.contributor.authorLee, Katherine Jen
dc.contributor.authorHorowitz, J Den
dc.contributor.authorMcKay, W Jen
dc.contributor.authorGoble, A Jen
dc.date.accessioned2015-05-16T02:41:59Z
dc.date.available2015-05-16T02:41:59Z
dc.date.issued1988-12-01en
dc.identifier.citationInternational Journal of Cardiology; 21(3): 279-91en
dc.identifier.govdoc3147949en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12936en
dc.description.abstractWe tested the hypothesis that preservation of left ventricular function results from treatment with intravenous streptokinase given in the first 2 hours from onset of acute transmural myocardial infarction together with nitroglycerine and verapamil. Thirty-three consecutive patients with onset of pain less than 2 hours prior to admission, received intravenous streptokinase 1.5 x 10(6) units with intravenous nitroglycerine and verapamil; 23 concurrently admitted "control" patients with pain onset 2-4 hours received intravenous nitroglycerine and verapamil only. Radionuclide ventriculographic assessment at 2 days revealed a significantly greater left ventricular ejection fraction in the streptokinase-treated patients (54.5 +/- 2.8 vs 46.1 +/- 2.9; P less than 0.05), which persisted at 28-35 days (50.1 +/- 2.3 vs 41.2 +/- 2.9; P less than 0.05). Streptokinase-treated patients had a significantly increased incidence of ischaemic events in the 35 days following infarction, but a lower incidence of death, congestive cardiac failure and non-fatal ventricular tachycardia than control group patients. Infarct-related artery patency assessed at 3-5 days was 94% in streptokinase-treated patients. We conclude that early presentation and treatment with intravenous streptokinase, nitroglycerine and verapamil is associated with a high incidence of successful thrombolysis and significant preservation of left ventricular function. Nitroglycerine and verapamil may augment the efficacy of streptokinase in this group of patients.en
dc.language.isoenen
dc.subject.otherAcute Diseaseen
dc.subject.otherDrug Therapy, Combinationen
dc.subject.otherFemaleen
dc.subject.otherHeart Ventricles.radionuclide imagingen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMyocardial Infarction.drug therapy.mortalityen
dc.subject.otherMyocardial Reperfusionen
dc.subject.otherNitroglycerin.therapeutic useen
dc.subject.otherStreptokinase.therapeutic useen
dc.subject.otherStroke Volume.drug effectsen
dc.subject.otherVerapamil.therapeutic useen
dc.titleMyocardial salvage with streptokinase combined with nitroglycerine and verapamil in acute myocardial infarction.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of cardiologyen
dc.identifier.affiliationAustin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages279-91en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3147949en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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