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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12930
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dc.contributor.authorYoung, N Aen
dc.contributor.authorLewis, S Jen
dc.contributor.authorHarris, Q Len
dc.contributor.authorJarrott, Ben
dc.contributor.authorVajda, F Jen
dc.date.accessioned2015-05-16T02:41:35Z
dc.date.available2015-05-16T02:41:35Z
dc.date.issued1987-11-01en
dc.identifier.citationNeuropharmacology; 26(11): 1611-4en
dc.identifier.govdoc3124016en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12930en
dc.description.abstractThe effects of chronic treatment with clonazepam and sodium valproate were studied on kindled amygdaloid seizures in rats. Fully kindled rats were given an intraperitoneal (i.p.) injection of either vehicle (1.0 ml/kg), clonazepam (0.3 mg/kg) or sodium valproate (200 mg/kg) twice daily for 12 days. Each rat was stimulated through an amygdaloid electrode 30 min after the morning dose. While both drugs initially blocked and kindled seizure (P less than 0.01), the results showed a significant trend (P less than 0.02) in the development of tolerance to the anticonvulsant action of clonazepam but no significant tolerance to the action of valproate.en
dc.language.isoenen
dc.subject.otherAmygdala.drug effectsen
dc.subject.otherAnimalsen
dc.subject.otherAnticonvulsantsen
dc.subject.otherClonazepam.pharmacologyen
dc.subject.otherDrug Toleranceen
dc.subject.otherKindling, Neurologic.drug effectsen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherSeizures.physiopathologyen
dc.subject.otherValproic Acid.pharmacologyen
dc.titleThe development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuropharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1611-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3124016en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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