Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12930
Title: The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat.
Austin Authors: Young, N A;Lewis, S J;Harris, Q L;Jarrott, B;Vajda, F J
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Nov-1987
Publication information: Neuropharmacology; 26(11): 1611-4
Abstract: The effects of chronic treatment with clonazepam and sodium valproate were studied on kindled amygdaloid seizures in rats. Fully kindled rats were given an intraperitoneal (i.p.) injection of either vehicle (1.0 ml/kg), clonazepam (0.3 mg/kg) or sodium valproate (200 mg/kg) twice daily for 12 days. Each rat was stimulated through an amygdaloid electrode 30 min after the morning dose. While both drugs initially blocked and kindled seizure (P less than 0.01), the results showed a significant trend (P less than 0.02) in the development of tolerance to the anticonvulsant action of clonazepam but no significant tolerance to the action of valproate.
Gov't Doc #: 3124016
URI: http://ahro.austin.org.au/austinjspui/handle/1/12930
URL: https://pubmed.ncbi.nlm.nih.gov/3124016
Type: Journal Article
Subjects: Amygdala.drug effects
Animals
Anticonvulsants
Clonazepam.pharmacology
Drug Tolerance
Kindling, Neurologic.drug effects
Male
Rats
Rats, Inbred Strains
Seizures.physiopathology
Valproic Acid.pharmacology
Appears in Collections:Journal articles

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