Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12921
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dc.contributor.authorDrummer, Olaf Hen
dc.contributor.authorKourtis, Sen
dc.date.accessioned2015-05-16T02:40:59Z
dc.date.available2015-05-16T02:40:59Z
dc.date.issued1988-08-09en
dc.identifier.citationEuropean Journal of Pharmacology; 153(1): 11-7en
dc.identifier.govdoc3063549en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12921en
dc.description.abstractThe ability of captopril and one of its metabolites, the disulphide dimer have been studied for their ability to affect angiotensin I and bradykinin responses. Captopril disulphide dimer (i.v.) potentiated the vasodilatory effects of bradykinin in urethane-anaesthetized rats, at doses of 0.1 and 0.3 mg/kg but did not inhibit the angiotensin I-mediated pressor response at these same concentrations. This activity of captopril disulphide dimer in vivo was not seen with bradykinin responses in isolated guinea pig ileum except at bath concentrations much higher than for captopril (10(-5) M). However captopril and captopril disulphide dimer at oral doses of 10 mg/kg both lowered systolic and diastolic blood pressures in spontaneously hypertensive rats. These studies are consistent with an in vivo bradykinin-potentiating activity of captopril disulphide dimer and suggest a possible antihypertensive activity of disulphide metabolites of captopril.en
dc.language.isoenen
dc.subject.otherAnesthesiaen
dc.subject.otherAngiotensin I.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherBradykinin.pharmacologyen
dc.subject.otherCaptopril.analogs & derivatives.pharmacologyen
dc.subject.otherDrug Synergismen
dc.subject.otherGuinea Pigsen
dc.subject.otherIleum.drug effectsen
dc.subject.otherIn Vitro Techniquesen
dc.subject.otherMaleen
dc.subject.otherMuscle, Smooth.drug effectsen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherTime Factorsen
dc.titleBradykinin-potentiating activity of captopril disulphide dimer (SQ 14,551).en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Pharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages11-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/3063549en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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