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Title: Bradykinin-potentiating activity of captopril disulphide dimer (SQ 14,551).
Austin Authors: Drummer, Olaf H;Kourtis, S
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 9-Aug-1988
Publication information: European Journal of Pharmacology; 153(1): 11-7
Abstract: The ability of captopril and one of its metabolites, the disulphide dimer have been studied for their ability to affect angiotensin I and bradykinin responses. Captopril disulphide dimer (i.v.) potentiated the vasodilatory effects of bradykinin in urethane-anaesthetized rats, at doses of 0.1 and 0.3 mg/kg but did not inhibit the angiotensin I-mediated pressor response at these same concentrations. This activity of captopril disulphide dimer in vivo was not seen with bradykinin responses in isolated guinea pig ileum except at bath concentrations much higher than for captopril (10(-5) M). However captopril and captopril disulphide dimer at oral doses of 10 mg/kg both lowered systolic and diastolic blood pressures in spontaneously hypertensive rats. These studies are consistent with an in vivo bradykinin-potentiating activity of captopril disulphide dimer and suggest a possible antihypertensive activity of disulphide metabolites of captopril.
Gov't Doc #: 3063549
Type: Journal Article
Subjects: Anesthesia
Angiotensin I.pharmacology
Blood Pressure.drug effects
Captopril.analogs & derivatives.pharmacology
Drug Synergism
Guinea Pigs
Ileum.drug effects
In Vitro Techniques
Muscle, Smooth.drug effects
Rats, Inbred SHR
Rats, Inbred Strains
Time Factors
Appears in Collections:Journal articles

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