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Title: Effect of glycaemic control on glomerular filtration rate in the streptozotocin diabetic rat.
Austin Authors: Jackson, B ;Franze, L;Allen, Terri J;O'Brien, R ;Cooper, Mark E;Hodsman, G P;Jerums, George 
Affiliation: Medicine (University of Melbourne)
Issue Date: 1-Apr-1988
Publication information: Clinical and Experimental Pharmacology & Physiology; 15(4): 361-5
Abstract: 1. Diabetes was induced in 32 adult Wistar-Kyoto rats with streptozotocin (60 mg/kg). Fourteen rats remained untreated, 10 received insulin three times per week, and eight received insulin daily. Fourteen non-diabetic rats served as controls. 2. Exchangeable sodium and plasma volume were elevated in the untreated diabetic rats. Treatment normalized these parameters. 3. Glomerular filtration rate (GFR) was elevated in the untreated diabetic group and the group receiving insulin three times per week compared with the control group. Daily insulin treatment restored GFR towards control values. 4. Plasma atrial natriuretic factor was similar in untreated diabetic rats and non-diabetic rats.
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.blood
Blood Glucose.metabolism
Blood Volume.drug effects
Body Weight.drug effects
Diabetes Mellitus, Experimental.blood.drug therapy.physiopathology
Glomerular Filtration Rate.drug effects
Insulin.therapeutic use
Rats, Inbred WKY
Appears in Collections:Journal articles

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