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Title: Attenuated renal response to atrial natriuretic peptide infusion in rats with heart failure.
Austin Authors: Kohzuki, M;Hodsman, G P;Harrison, R W;Johnston, Colin I
Affiliation: University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1988
Publication information: Clinical and Experimental Pharmacology & Physiology; 15(4): 323-6
Abstract: 1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.
Gov't Doc #: 2978744
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.administration & dosage.pharmacology
Blood Pressure.drug effects
Chronic Disease
Coronary Vessels.physiology
Diuresis.drug effects
Dose-Response Relationship, Drug
Heart Failure.physiopathology
Infusions, Intravenous
Kidney.drug effects
Myocardial Infarction.physiopathology
Natriuresis.drug effects
Rats, Inbred Strains
Appears in Collections:Journal articles

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