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https://ahro.austin.org.au/austinjspui/handle/1/12914| Title: | Attenuated renal response to atrial natriuretic peptide infusion in rats with heart failure. | Austin Authors: | Kohzuki, M;Hodsman, G P;Harrison, R W;Johnston, Colin I | Affiliation: | University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Apr-1988 | Publication information: | Clinical and Experimental Pharmacology & Physiology; 15(4): 323-6 | Abstract: | 1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP. | Gov't Doc #: | 2978744 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12914 | Journal: | Clinical and Experimental Pharmacology & Physiology | URL: | https://pubmed.ncbi.nlm.nih.gov/2978744 | Type: | Journal Article | Subjects: | Animals Atrial Natriuretic Factor.administration & dosage.pharmacology Blood Pressure.drug effects Chronic Disease Coronary Vessels.physiology Diuresis.drug effects Dose-Response Relationship, Drug Female Heart Failure.physiopathology Infusions, Intravenous Kidney.drug effects Myocardial Infarction.physiopathology Natriuresis.drug effects Rats Rats, Inbred Strains |
| Appears in Collections: | Journal articles |
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