Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12906
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dc.contributor.authorBeart, P Men
dc.contributor.authorCook, C Jen
dc.contributor.authorCincotta, Men
dc.contributor.authorde Vries, D Jen
dc.contributor.authorTepper, Pen
dc.contributor.authorDijkstra, Den
dc.contributor.authorHorn, A Sen
dc.date.accessioned2015-05-16T02:39:30Z
dc.date.available2015-05-16T02:39:30Z
dc.date.issued1987-11-01en
dc.identifier.citationNaunyn-schmiedeberg's Archives of Pharmacology; 336(5): 487-93en
dc.identifier.govdoc2963964en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12906en
dc.description.abstractThe affinity of a series of N,N-disubstituted 2-aminotetralins for the rat striatal D2 dopamine receptor labelled by [3H]spiperone has been determined. Displacement data for the more potent 2-aminotetralins were better described by a model where the compounds competed for [3H]spiperone at two sites. The high affinity component accounted for approximately 80% of the total sites. Displacement curves for all 2-aminotetralins were shifted to the right by 100 microM guanosine-5'-triphosphate; a result attributable to the redistribution of 13-47% of the sites to a low affinity form. These data are consistent with the N,N-disubstituted 2-aminotetralins being agonists at the D2 dopamine receptor. In particular, the affinities of the 5-hydroxy-2-aminotetralins were as high as those of traditional dopamine agonists.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBinding, Competitiveen
dc.subject.otherChemical Phenomenaen
dc.subject.otherChemistryen
dc.subject.otherCorpus Striatum.metabolismen
dc.subject.otherGuanosine Triphosphate.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherNaphthalenes.pharmacologyen
dc.subject.otherPhenethylamines.pharmacologyen
dc.subject.otherRadioligand Assayen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Dopamine.drug effects.metabolismen
dc.subject.otherReceptors, Dopamine D2en
dc.subject.otherSpiperone.metabolismen
dc.subject.otherTetrahydronaphthalenes.pharmacologyen
dc.subject.otherThiophenes.pharmacologyen
dc.titleRadioreceptor binding reveals the potencies of N,N-disubstituted 2-aminotetralins as D2 dopamine agonists.en
dc.typeJournal Articleen
dc.identifier.journaltitleNaunyn-Schmiedeberg's archives of pharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages487-93en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2963964en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
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