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https://ahro.austin.org.au/austinjspui/handle/1/12900| Title: | Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. | Austin Authors: | Norman, Trevor R ;Chiu, E;James, R H;Gregory, M S | Affiliation: | Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 16-May-1987 | Publication information: | European Journal of Clinical Pharmacology; 32(6): 583-6 | Abstract: | The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h. | Gov't Doc #: | 2958291 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12900 | Journal: | European journal of clinical pharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2958291 | Type: | Journal Article | Subjects: | Administration, Oral Adult Aged Benzamides.pharmacokinetics Female Half-Life Humans Huntington Disease.metabolism Kidney.metabolism Male Middle Aged Tiapamil Hydrochloride.pharmacokinetics |
| Appears in Collections: | Journal articles |
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