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Title: Platelet serotonin uptake in panic disorder: comparison with normal controls and the effect of treatment.
Austin Authors: Norman, Trevor R ;Gregory, M S;Judd, F K;Burrows, Graham D;McIntyre, I M
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic.
Issue Date: 1-Dec-1988
Publication information: The Australian and New Zealand Journal of Psychiatry; 22(4): 390-5
Abstract: Platelet serotonin uptake was measured in 59 patients with panic attacks and compared to 26 controls. Scatchard analysis of the data showed that the maximal rate of uptake (Vmax) of serotonin was significantly higher in patients than controls. The affinity constant (Km) was not different. In a sub-group of 24 patients, benzodiazepine treatment did not alter the kinetics of platelet serotonin uptake. These findings suggest an abnormality in serotonergic function in patients with panic attacks. Insofar as the platelet is a model of central neuronal function they support serotonergic hyperactivity as a biochemical basis of panic attacks.
Gov't Doc #: 2907288
Journal: The Australian and New Zealand Journal of Psychiatry
Type: Journal Article
Subjects: Adolescent
Agoraphobia.blood.drug therapy
Anti-Anxiety Agents.therapeutic use
Blood Platelets.drug effects.metabolism
Fear.drug effects
Middle Aged
Panic.drug effects.physiology
Phobic Disorders.drug therapy
Receptors, Serotonin.drug effects.metabolism
Appears in Collections:Journal articles

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