Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12889
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dc.contributor.authorAllen, A Men
dc.contributor.authorDampney, R Aen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T02:38:24Z
dc.date.available2015-05-16T02:38:24Z
dc.date.issued1988-11-01en
dc.identifier.citationThe American Journal of Physiology; 255(5 Pt 2): H1011-7en
dc.identifier.govdoc2903678en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12889en
dc.description.abstractCentral administration of angiotensin II (ANG II) increases arterial blood pressure via increased sympathetic activity. We have examined the possibility that one site of action of ANG II is the subretrofacial (SRF) nucleus in the rostral ventrolateral medulla, since this nucleus is known to play a critical role in the tonic and phasic control of arterial pressure. In vitro autoradiography, employing 125I-labeled [Sar1, Ile8]ANG II as radioligand, was used to localize binding sites for ANG II in the cat ventrolateral medulla. A high density of ANG II-receptor binding sites was found confined to the SRF nucleus. In a second group of experiments in anesthetized cats, microinjections of ANG II, in doses ranging from 10 to 50 pmol, were made into histologically identified sites within and outside the SRF nucleus. Microinjections into the nucleus resulted in a dose-dependent increase in arterial pressure, which was abolished by systemic administration of the ganglion-blocking drug hexamethonium bromide. In contrast, microinjections just outside the SRF nucleus had no effect on arterial pressure. It is concluded that activation of ANG II-receptor binding sites within the SRF nucleus leads to an increase in arterial pressure via increased sympathetic efferent activity.en
dc.language.isoenen
dc.subject.other1-Sarcosine-8-Isoleucine Angiotensin II.metabolismen
dc.subject.otherAngiotensin II.administration & dosage.metabolism.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherAtropine.pharmacologyen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCatsen
dc.subject.otherDose-Response Relationship, Drugen
dc.subject.otherGlutamates.pharmacologyen
dc.subject.otherGlutamic Aciden
dc.subject.otherHexamethoniumen
dc.subject.otherHexamethonium Compounds.pharmacologyen
dc.subject.otherMedulla Oblongata.drug effects.physiologyen
dc.subject.otherMicroinjectionsen
dc.subject.otherReceptors, Angiotensin.metabolismen
dc.subject.otherTissue Distributionen
dc.titleAngiotensin receptor binding and pressor effects in cat subretrofacial nucleus.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Physiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.en
dc.description.pagesH1011-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2903678en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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