Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12887
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dc.contributor.authorYoung, N Aen
dc.contributor.authorLewis, S Jen
dc.contributor.authorHarris, Q Len
dc.contributor.authorJarrott, Ben
dc.contributor.authorVajda, F Jen
dc.date.accessioned2015-05-16T02:38:16Z
dc.date.available2015-05-16T02:38:16Z
dc.date.issued1988-05-01en
dc.identifier.citationThe Journal of Pharmacy and Pharmacology; 40(5): 365-7en
dc.identifier.govdoc2899635en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12887en
dc.description.abstractThe effects of chronic treatment with two benzodiazepines were studied on kindled amygdaloid seizures in rats. Clobazam (4 mg kg-1), clonazepam (0.3 mg kg-1) or vehicle (1 mL kg-1) was administered, by intraperitoneal injection, to fully kindled rats twice daily for nineteen days. Each rat was electrically stimulated 30 min after the morning dose on alternate days of treatment. Tolerance developed rapidly to the anticonvulsant effects of clobazam after only three days of treatment, following which only a small residual protection was maintained. Tolerance to clonazepam developed gradually over the course of the experiment, although this effect was relatively minor.en
dc.language.isoenen
dc.subject.otherAmygdala.drug effectsen
dc.subject.otherAnimalsen
dc.subject.otherAnti-Anxiety Agentsen
dc.subject.otherAnticonvulsants.pharmacologyen
dc.subject.otherBenzodiazepinesen
dc.subject.otherBenzodiazepinones.pharmacologyen
dc.subject.otherClonazepam.pharmacologyen
dc.subject.otherDrug Toleranceen
dc.subject.otherKindling, Neurologicen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleDifferences in the development of tolerance to two anticonvulsant benzodiazepines in the amygdaloid kindled rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of pharmacy and pharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages365-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2899635en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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