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Title: An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence.
Austin Authors: Beart, P M;Nicolopoulos, L S;West, D C;Headley, P M
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 29-Feb-1988
Publication information: Neuroscience Letters; 85(2): 205-11
Abstract: The projection from ventromedial hypothalamus (VMH) to periaqueductal gray (PAG) has been implicated in various physiological processes in the rat, but the neurotransmitter mediating the excitatory response in PAG has not been identified. This pathway has been studied using a combination of anatomical and electrophysiological techniques. The retrograde labelling by D-[3H]aspartate in VMH, following injections into PAG, was particularly dense, suggesting that an excitatory amino acid may be the transmitter. This postulate is strengthened since VMH-evoked synaptic responses in PAG were reduced by microelectrophoretically administered antagonists of excitatory amino acids. Receptors of the N-methyl-D-aspartate and non-N-methyl-D-aspartate types appear to have a functional role in this projection.
Gov't Doc #: 2897646
Journal: Neuroscience letters
Type: Journal Article
Subjects: 2-Amino-5-phosphonovalerate
Action Potentials.drug effects
Aspartic Acid.analogs & derivatives.metabolism.pharmacology.physiology
Electric Stimulation
Kainic Acid.pharmacology
Neural Pathways.anatomy & histology.physiology
Periaqueductal Gray.cytology.metabolism.physiology
Rats, Inbred Strains
Reaction Time
Valine.analogs & derivatives.pharmacology
Ventromedial Hypothalamic Nucleus.cytology.metabolism.physiology
Appears in Collections:Journal articles

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