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Title: Calcium antagonists and hypertension.
Austin Authors: Nayler, W G;Dillon, J S;Sturrock, W J
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Feb-1988
Publication information: Clinical and Experimental Pharmacology & Physiology; 15(2): 93-103
Abstract: 1. Calcium antagonists, including verapamil, are now used widely in the management of patients with hypertension. 2. Six weeks of chronic therapy with verapamil (50 mg/kg per day, orally) to produce a plasma level of 80-100 ng/ml in Sprague-Dawley rats depletes cardiac noradrenaline (NA) without apparently causing beta 1 adrenoceptor 'up' regulation. 3. The effect of verapamil on cardiac NA is rapidly reversed upon verapamil withdrawal. 4. Chronic therapy with nisoldipine (100 mg/kg per day, orally) had no effect on cardiac NA. 5. Verapamil (50 mg/kg per day, orally) and nisoldipine (100 mg/kg per day, orally) therapy for 6 weeks prevented the time-dependent increase in systolic blood pressure in SHR rats. 6. Binding studies with (-)[3H]-D888 (desmethoxyverapamil) indicated that the affinity of the phenylalkylamine binding sites is higher in hearts of SHR relative to hearts from age-matched (25 weeks) WKY and SD, without any change in density.
Gov't Doc #: 2856052
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Aging.metabolism
Aniline Compounds.pharmacology
Blood Pressure.drug effects
Calcium Channel Blockers.pharmacology
Dihydroalprenolol.diagnostic use
Heart.drug effects
In Vitro Techniques
Membranes.drug effects.metabolism
Rats, Inbred Strains
Rats, Inbred WKY
Receptors, Adrenergic, beta.drug effects.metabolism
Appears in Collections:Journal articles

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