Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12879
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dc.contributor.authorJackson, Ben
dc.contributor.authorDebrevi, Len
dc.date.accessioned2015-05-16T02:37:45Z
dc.date.available2015-05-16T02:37:45Z
dc.date.issued1988-02-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 15(2): 131-6en
dc.identifier.govdoc2856051en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12879en
dc.description.abstract1. Nephrotoxic serum nephritis was induced immunologically in uninephrectomized Sprague-Dawley rats (n = 24). One-half were assigned randomly to treatment with enalapril (5 mg/kg per 24 h). 2. Untreated rats (n = 12) developed a progressive fall in creatinine clearance, a progressive rise in systolic blood pressure and marked proteinuria over a 6 week period. The mortality rate was 42% at 5 weeks and 66% at 6 weeks. 3. Enalapril-treated rats (n = 12) had no significant reduction in systolic blood pressure, and a similar reduction in creatinine clearance to that in untreated rats. Mortality was 50% at 5 weeks, and 92% at 6 weeks. 4. Proteinuria but not the blood pressure rise was significantly reduced by enalapril treatment. 5. Converting enzyme inhibitors may have a specific role in the treatment of nephritic diseases.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherCreatinine.blooden
dc.subject.otherEnalapril.pharmacologyen
dc.subject.otherFemaleen
dc.subject.otherGlomerular Filtration Rate.drug effectsen
dc.subject.otherKidney Failure, Chronic.chemically induced.mortality.physiopathologyen
dc.subject.otherNephritis.chemically induceden
dc.subject.otherProteinuria.chemically induceden
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.titleEffect of enalapril treatment on progression of the nephrotoxic serum nephritis model of renal failure in the rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationUniversity of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages131-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2856051en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
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