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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Manallack, D T | en |
dc.contributor.author | Beart, P M | en |
dc.date.accessioned | 2015-05-16T02:37:18Z | |
dc.date.available | 2015-05-16T02:37:18Z | |
dc.date.issued | 1988-11-01 | en |
dc.identifier.citation | Neuropharmacology; 27(11): 1201-3 | en |
dc.identifier.govdoc | 2849732 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12872 | en |
dc.description.abstract | The effects of subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine (DTG) on the central R(+)[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine (R(+)[3H]-3-PPP) binding site were investigated in the rat. Subchronic treatment with rimcazole was characterized by a 30% increase in the density and a two-fold decrease in the affinity of R(+)[3H]-3-PPP binding sites relative to saline-treated animals. DTG, a more potent sigma ligand, produced a similar alteration to the affinity but a 130% increase in the density of R(+)[3H]-3-PPP binding sites. These data thus provide evidence for the functional involvement of sigma receptors in the central nervous system. | en |
dc.language.iso | en | en |
dc.subject.other | Animals | en |
dc.subject.other | Carbazoles.administration & dosage.pharmacology | en |
dc.subject.other | Guanidines.administration & dosage.pharmacology | en |
dc.subject.other | Male | en |
dc.subject.other | Piperidines.metabolism | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred Strains | en |
dc.subject.other | Receptors, Opioid.drug effects | en |
dc.subject.other | Receptors, sigma | en |
dc.title | Up-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Neuropharmacology | en |
dc.identifier.affiliation | University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 1201-3 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/2849732 | en |
dc.type.austin | Journal Article | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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