Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12872
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dc.contributor.authorManallack, D Ten
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-16T02:37:18Z
dc.date.available2015-05-16T02:37:18Z
dc.date.issued1988-11-01en
dc.identifier.citationNeuropharmacology; 27(11): 1201-3en
dc.identifier.govdoc2849732en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12872en
dc.description.abstractThe effects of subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine (DTG) on the central R(+)[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine (R(+)[3H]-3-PPP) binding site were investigated in the rat. Subchronic treatment with rimcazole was characterized by a 30% increase in the density and a two-fold decrease in the affinity of R(+)[3H]-3-PPP binding sites relative to saline-treated animals. DTG, a more potent sigma ligand, produced a similar alteration to the affinity but a 130% increase in the density of R(+)[3H]-3-PPP binding sites. These data thus provide evidence for the functional involvement of sigma receptors in the central nervous system.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCarbazoles.administration & dosage.pharmacologyen
dc.subject.otherGuanidines.administration & dosage.pharmacologyen
dc.subject.otherMaleen
dc.subject.otherPiperidines.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Opioid.drug effectsen
dc.subject.otherReceptors, sigmaen
dc.titleUp-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuropharmacologyen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1201-3en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2849732en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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