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Title: Up-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine.
Austin Authors: Manallack, D T;Beart, P M
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Nov-1988
Publication information: Neuropharmacology; 27(11): 1201-3
Abstract: The effects of subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine (DTG) on the central R(+)[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine (R(+)[3H]-3-PPP) binding site were investigated in the rat. Subchronic treatment with rimcazole was characterized by a 30% increase in the density and a two-fold decrease in the affinity of R(+)[3H]-3-PPP binding sites relative to saline-treated animals. DTG, a more potent sigma ligand, produced a similar alteration to the affinity but a 130% increase in the density of R(+)[3H]-3-PPP binding sites. These data thus provide evidence for the functional involvement of sigma receptors in the central nervous system.
Gov't Doc #: 2849732
Journal: Neuropharmacology
Type: Journal Article
Subjects: Animals
Carbazoles.administration & dosage.pharmacology
Guanidines.administration & dosage.pharmacology
Rats, Inbred Strains
Receptors, Opioid.drug effects
Receptors, sigma
Appears in Collections:Journal articles

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