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Title: | Up-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine. | Austin Authors: | Manallack, D T;Beart, P M | Affiliation: | University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Nov-1988 | Publication information: | Neuropharmacology; 27(11): 1201-3 | Abstract: | The effects of subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine (DTG) on the central R(+)[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine (R(+)[3H]-3-PPP) binding site were investigated in the rat. Subchronic treatment with rimcazole was characterized by a 30% increase in the density and a two-fold decrease in the affinity of R(+)[3H]-3-PPP binding sites relative to saline-treated animals. DTG, a more potent sigma ligand, produced a similar alteration to the affinity but a 130% increase in the density of R(+)[3H]-3-PPP binding sites. These data thus provide evidence for the functional involvement of sigma receptors in the central nervous system. | Gov't Doc #: | 2849732 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12872 | Journal: | Neuropharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2849732 | Type: | Journal Article | Subjects: | Animals Carbazoles.administration & dosage.pharmacology Guanidines.administration & dosage.pharmacology Male Piperidines.metabolism Rats Rats, Inbred Strains Receptors, Opioid.drug effects Receptors, sigma |
Appears in Collections: | Journal articles |
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