Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12867
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dc.contributor.authorBeart, P Men
dc.contributor.authorSheehan, K Aen
dc.contributor.authorManallack, D Ten
dc.date.accessioned2015-05-16T02:36:58Z
dc.date.available2015-05-16T02:36:58Z
dc.date.issued1988-12-01en
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism; 8(6): 879-82en
dc.identifier.govdoc2848048en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12867en
dc.description.abstractRadioreceptor methods were used to quantitate the N-methyl-D-aspartate (NMDA) receptor-complex of ovine cerebral microvessels and cerebral gray matter. Specific binding of D[3H]2-amino-5-phosphono-pentanoate and [3H]1-[1-(2-thienyl)cyclohexyl]piperidine, ligands for the NMDA primary acceptor site and ionophore, respectively, was found in cerebral gray matter but was not detectable in membranes prepared from brain microvessels enriched in capillaries. Sigma receptors, another locus of action for phencyclidine congeners, were also not present on microvessels but were found in cortical homogenates. On the other hand, cerebral microvessels and gray matter contained significant numbers of beta-adrenoceptors. Our results indicate the NMDA receptors and NMDA antagonists are unlikely to regulate the function of the cerebral microvasculature.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBlood Vessels.analysisen
dc.subject.otherBrain.blood supplyen
dc.subject.otherBrain Chemistryen
dc.subject.otherReceptors, N-Methyl-D-Aspartateen
dc.subject.otherReceptors, Neurotransmitter.analysisen
dc.subject.otherSheepen
dc.titleAbsence of N-methyl-D-aspartate receptors on ovine cerebral microvessels.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolismen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1038/jcbfm.1988.146en
dc.description.pages879-82en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2848048en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
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