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Title: Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens.
Austin Authors: Maccarrone, C;Jarrott, B
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1988
Publication information: Life Sciences; 42(25): 2633-8
Abstract: Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidine (+43%), and pempidine (+82%). The levels of NPY-ir in the rat vas deferens were not affected by either surgical or pharmacological treatment. These results suggest NPY is released from sympathetic nerves in the iris but not vas deferens during normal sympathetic activity.
Gov't Doc #: 2838710
Journal: Life sciences
Type: Journal Article
Subjects: Animals
Ganglia, Sympathetic
Immunologic Techniques
Neuropeptide Y.metabolism
Sympathetic Nervous System.physiology
Synaptic Transmission.drug effects
Vas Deferens.innervation.metabolism
Appears in Collections:Journal articles

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