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Title: Overlapping distributions of receptors for atrial natriuretic peptide and angiotensin II visualized by in vitro autoradiography: morphological basis of physiological antagonism.
Austin Authors: Mendelsohn, Frederick AO;Allen, A M;Chai, Syn Y;Sexton, P M;Figdor, R
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1987
Publication information: Canadian Journal of Physiology and Pharmacology; 65(8): 1517-21
Abstract: Atrial natriuretic peptides exert actions on many key organs involved in blood pressure and water and electrolyte balance. Many of these actions result in a physiological antagonism of angiotensin. To investigate the morphological basis of this interaction, we have mapped the distribution of receptors for atrial natriuretic peptide and angiotensin II in a number of target organs, using 125I-labelled rat atrial natriuretic peptide (99-126) and 125I-labelled [Sar1,Ile8]angiotensin II. In the kidney both atrial natriuretic peptide and angiotensin II receptors were observed overlying glomeruli, vasa recta bundles (high densities), and the outer cortex (moderate density). In the other tissues studied, atrial natriuretic peptide and angiotensin II receptors were codistributed in the adrenal zona glomerulosa, cerebral circumventricular organs including the subfornical organ, organum vasculosum of the lamina terminalis and area postrema, and the external plexiform layer of the olfactory bulb. The concurrent distribution of specific receptors for both peptides at these sites provides the basis for atrial natriuretic peptide to exert a functional antagonism of the actions of angiotensin II on blood pressure and water and electrolyte homeostasis at multiple sites.
Gov't Doc #: 2825937
Type: Journal Article
Subjects: Adrenal Glands.metabolism
Angiotensin II.metabolism.pharmacology
Atrial Natriuretic Factor.metabolism
Blood Pressure.drug effects
Iodine Radioisotopes
Organ Specificity
Rats, Inbred Strains
Receptors, Angiotensin.metabolism
Receptors, Atrial Natriuretic Factor
Receptors, Cell Surface.metabolism
Appears in Collections:Journal articles

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