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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shulkes, Arthur | en |
dc.contributor.author | Lewis, S J | en |
dc.contributor.author | Jarrott, B | en |
dc.date.accessioned | 2015-05-16T02:34:55Z | |
dc.date.available | 2015-05-16T02:34:55Z | |
dc.date.issued | 1989-07-01 | en |
dc.identifier.citation | Neuropeptides; 14(1): 59-64 | en |
dc.identifier.govdoc | 2779758 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/12836 | en |
dc.description.abstract | The regional brain and spinal cord concentrations of cholecystokinin-octapeptide (CCK-8) were measured in age-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats. The relative order of distribution of CCK-8 in the WKY strain was hippocampus (20.5 +/- 1.3 pmol/g) greater than cortex greater than striatum = hypothalamus greater than midbrain = thalamus greater than spinal cord greater than medulla oblongata/pons (MO/P, 1.6 +/- 0.2 pmol/g) whereas in the SH strain this order was hippocampus (12.9 +/- 0.8 pmol/g) greater than cortex = striatum greater than hypothalamus greater than midbrain greater than thalamus = spinal cord greater than MO/P (1.4 +/- 0.2 pmol/g). The concentrations of CCK-8 in the cerebellum were at the level of assay sensitivity (0.5 pmol/g in both strains). In comparison to the WKY rats, the SH strain had significantly lower levels of CCK-8 in the hippocampus (-37%), cortex (-28%), spinal cord (-23%) and pituitary (-57%). The lowered levels of CCK-8 in the brain of the SH rat may be causally related to, or result from, the cardiovascular, behavioural or morphological abnormalities of this strain. | en |
dc.language.iso | en | en |
dc.subject.other | Age Factors | en |
dc.subject.other | Animals | en |
dc.subject.other | Brain Chemistry | en |
dc.subject.other | Female | en |
dc.subject.other | Hypertension.metabolism | en |
dc.subject.other | Rats | en |
dc.subject.other | Rats, Inbred SHR | en |
dc.subject.other | Rats, Inbred WKY | en |
dc.subject.other | Sincalide.analysis | en |
dc.subject.other | Spinal Cord.analysis | en |
dc.title | Strain differences in central nervous system concentrations of cholecystokinin between normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rats. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Neuropeptides | en |
dc.identifier.affiliation | Department of Surgery and Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australia | en |
dc.description.pages | 59-64 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/2779758 | en |
dc.type.austin | Journal Article | en |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Journal articles |
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