Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12825
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dc.contributor.authorBuchanan, Russell R Cen
dc.contributor.authorRiglar, A Gen
dc.date.accessioned2015-05-16T02:34:13Z
dc.date.available2015-05-16T02:34:13Z
dc.date.issued1989-06-01en
dc.identifier.citationBritish Journal of Rheumatology; 28(3): 221-6en
dc.identifier.govdoc2730983en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12825en
dc.description.abstractA retrospective survey of all patients with positive anti-centromere antibody (ACA) determinations over a 5-year period was undertaken. Of the 52 patients identified, seven denied symptoms of Raynaud's phenomenon, all of whom had antibody titres of 2560 or less. One of these showed a 16-fold increase in titre with the onset of Raynaud's, 12 years after original presentation. The remaining 45 patients experienced Raynaud's on cold exposure. Within this group, seven developed thrombotic vascular disease, five of whom were associated with an ACA titre of 20,480 or above. Another two with similar high ACA titres developed hyper-reninaemic hypertension, suggesting disease of the renal vasculature and associated ischaemia. Where it was possible to ascertain, seven of eight with high titre ACA developed sclerodactyly. In contrast, this was not seen in those with low titre ACA of 2560 or less and who also denied Raynaud's phenomenon.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAntibodies.analysisen
dc.subject.otherCentromere.immunologyen
dc.subject.otherChromosomes.immunologyen
dc.subject.otherFingersen
dc.subject.otherHumansen
dc.subject.otherMiddle Ageden
dc.subject.otherRaynaud Disease.immunologyen
dc.subject.otherRetrospective Studiesen
dc.subject.otherScleroderma, Localized.immunologyen
dc.subject.otherThrombosis.immunologyen
dc.titleThe titre of anti-centromere antibodies: its relationship to Raynaud's phenomenon and vascular occlusion.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish journal of rheumatologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages221-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2730983en
dc.type.austinJournal Articleen
local.name.researcherBuchanan, Russell R C
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptRheumatology-
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